Defending champions Liverpool will travel to face struggling Southampton in the Carabao Cup quarter-finals.
In another match, Arsenal will host Crystal Palace in a London derby, while Newcastle United will play at home against Brentford.
The quarter-final matches are scheduled for the week of December 16.
This marks the first time in 14 years that no EFL clubs have reached the League Cup quarter-finals.
In the fourth round, Tottenham Hotspur defeated Manchester City, while Manchester United, who won 5-2 against Leicester under interim manager Ruud van Nistelrooy, hope to have Ruben Amorim as their new manager by then.
EFL Cup Quarter-Finals:
- Tottenham vs. Manchester United
- Arsenal vs. Crystal Palace
- Newcastle vs. Brentford
- Southampton vs. Liverpool
