Holders Chelsea will play Real Madrid in the Champions League quarter-finals, while Manchester City have been drawn against Atletico Madrid.
Liverpool, who beat Italian champions Inter Milan to progress from the last 16, will face Portuguese side Benfica.
The other quarter-final tie sees Spanish side Villarreal, last season’s Europa League winners, take on Bayern Munich after shocking Juventus in the last 16.
Manchester City will face Chelsea in the semi-final if both sides are successful in the quarters – which would be a repeat of last season’s final in Porto.
Chelsea overcame Real Madrid in last season’s semi-final, beating the 13-time winners of this competition 3-1 on aggregate, and will be looking to do the same this time out in the quarters.
“It’s a tough one,” said Chelsea boss Thomas Tuchel. “The challenge couldn’t be much higher, playing the second leg in the Bernabeu with spectators. It’s a big challenge and a big excitement around this match and this fixture. We know what’s coming and it will be an exciting match and a tough challenge.”
City take on Atletico, who proved to be too much for Manchester United in the previous round, after easing past Portuguese champions Sporting Lisbon with a 5-0 aggregate score over two legs.
Pep Guardiola has not faced Atletico since becoming City manager, but was frustrated by Diego Simeone’s side in the semi-final of this competition in 2016 when in charge of Bayern Munich, as the La Liga champions progressed to the final on away goals despite the Germans dominating possession.
Both of Liverpool and Manchester City’s first-leg clashes will take place on Tuesday April 5, with the return legs eight days later. That means the epic Super Sunday title showdown between the two teams will remain on Sunday April 10, kick-off 4.30pm live on Sky Sports.
The semi-finals will then be played on Tuesday April 26 and Wednesday April 27 with the second legs on May 3 and 4.
Champions League quarter-final draw
Chelsea vs Real Madrid
Manchester City vs Atletico Madrid
Villarreal vs Bayern Munich
Benfica vs Liverpool
